Repairing the Brain

A New Paradigm for Treating Chronic Pain, Neurologic Diseases and Mental Health Disorders

Repair damaged brain tracts with noninvasive, image-guided, personalized TMS therapy, and with the ability to also focally deliver drugs and gene payloads anywhere in the head

The Future of Transcranial Magnetic Stimulation (TMS)

NeurTX is developing a noninvasive, office-based, MRI-guided TMS for focal regeneration and/or myelination of damaged brain tracts, with real-time monitoring of location, dose and response.

The same system may be used to tomographically deliver drugs and and genes across the blood Brain Barrier (BBB).

What indications will we address?

NeurTX enables image guided, selective, deep, focused therapy for entire tracts and may enable treatment for a range of mood, thought, development, cognition, movement traumatic injury and substance use disorders.

Current and Future TMS Applications

TMS is currently FDA-cleared for Major Depressive Disorder (MDD), Obsessive Compulsive Diorder (OCD), Anxious Depression and Smoking Addiction. However, TMS has not been FDA cleared as a first-line therapy for any clinical indication.

TMS is CE-marked in Europe for many other indications, including Alzheimer’s Disease, Autism, Bipolar Disorder, Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Post-stroke rehabilitation, Post-traumatic Stress Disorder and negative symptoms of Schizophrenia.

The NeurTX product is not approved by FDA at this time. By United States law, the device portrayed herein and the information included in this presentation are limited to investigational use only.

TMS Problems we are addressing

Existing TMS systems don’t take brain anatomy or neuro-physiology variations into account.  They also do not facilitate placement, ensure maximum dosage as intened, or measure therapeutic impact against objective biomarkers.  This is addressed with MRI guided TMS. Indeed, MRI-informed TMS has also shown potential for improved response and remission, and accelerated treatments.  However, these treatments are limited by:
  • Limited access (and no available integration of TMS) to MRI
  • Existing TMS systems only reaches superficial parts of the brain. Direct stimulation of the deep brain is especially desirable for treating neurodegenerative disease, pain, fear, anxiety
  • Existing TMS systems can only stimulate one region at a time (not entire brain circuits, simultaneously)

Drug/Gene Delivery Problems we are addressing

Many drugs and genes are of potential interest for neurological and mental health disorders.  However, these often have difficulty accessing desired regions of the brain. The blood-brain-barrier (BBB) severely limits the number and types of drugs that can modulate brain function.
  • The BBB prevents entry into the brain of most drugs from the blood
  • The BBB makes difficult the development of new treatments of brain diseases, and radiopharmaceuticals for neuroimaging
  • Drugs reaching unintended parts of the brain and body can cause side effects
NeurTX has shown potential to increase transfer of drugs and genes across the BBB.

Enabling Neuroscience-based,

AI-enabled, precision personalized workflow and therapy

Unlike existing TMS systems, NeurTX will, for the first time, enable precise and focal delivery of tailored and optimized pulse sequences at desired locations, and measure the impact of therapy on intended biomarkers. This will enable treatment panning, tomographic delivery, real-time treatment monitoring and follow-up assessment, all in one system in an office or clinic setting. It will also facilitate, finally, a bioscience-based paradigm for neurotherapy and mental health therapy

About Us

NeurTX is being spun-out from Weinberg Medical Physics (WMP), a medical device incubator located in Rockville, MD. WMP has expertise in medical imaging applications. Representative successes include:

• Developed medical imaging devices used by millions of people.

• FDA-cleared multiple devices for human use

• Licensed numerous patents to companies; sold medical device patent to Philips Medical

• Designed, built and licensed MRI system that has attained FDA clearance for guided therapy applications

WMP has previously launched successful companies, including: Promaxo, Radialis Medical, Brain Biosciences, and Longmile
Veterinary Imaging.

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